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FRIUS is a leader in the field of chronic pain rehabilitation. Over 250 peer-reviewed scientific articles, books, and book chapters, with data from thousands of patients, have been published since FRIUS was founded in 1983. The knowledge gained from this research effort provides much of the backbone of evidence-based medicine (EBM) for measurement of function, use/misuse of certain medications in chronic pain, and socioeconomically relevant outcomes of Functional Restoration treatment. This research is also used for internal training, as it gives FRIUS physicians and staff a unique understanding of the nature of chronic pain and the pain-related obstacles that our patients encounter in their activities of daily living. It also helps FRIUS to continually refine its ability to comprehensibly assess patients as they enter the program, to create the most effective individualized treatment plans, and to quantify and evaluate treatment outcomes. In addition, by repeatedly demonstrating the positive treatment outcomes that a Functional Restoration program can produce, FRIUS’s published research has influenced how chronic pain treatment is approached by many other physicians and pain management facilities.